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Chemicals and Pharmaceuticals

Novartis announced on October 30th that it has entered a memorandum of understanding with Advanced Accelerator Applications (AAA) under which Novartis intends to commence a tender offer for 100% of the share capital of AAA subject to certain conditions. Advanced Accelerator Applications is a radiopharmaceutical company that develops, produces and commercializes Molecular Nuclear Medicines including Lutathera®, a first-in-class RLT product for neuroendocrine tumors.

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Novartis has announced long-term study results supporting the positive safety and efficacy of Revolade (eltrombopag) in adults with chronic/persistent (enrolling patients that were 6 or more months from diagnosis) immune (idiopathic) thrombocytopenia (ITP) were published online in Blood.

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Sanofi and Regeneron Pharmaceuticals, Inc. has announced positive results from a Phase 2 investigational study of dupilumab in adults with active moderate-to-severe eosinophilic esophagitis.

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AkzoNobel's Specialty Chemicals business has entered the design phase of a further capacity expansion in Germany to produce chloromethanes - a key ingredient in the manufacture of pharmaceuticals and electronics.

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Considering the planned acquisition of Monsanto, Bayer has signed an agreement to sell selected Crop Science businesses to BASF for €5.9 billion. The assets to be sold generated net sales of approximately €1.3 billion in 2016.

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Janssen Biotech, Inc. has announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for Apalutamide, an investigational, next-generation oral androgen receptor (AR) inhibitor for men with non-metastatic castration-resistant prostate cancer (CRPC).

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Fluor Corporation (NYSE: FLR) announced today that it was selected by LyondellBasell (NYSE: LYB) to perform the engineering and procurement for its propylene oxide (PO) and tertiary butyl alcohol (TBA) project located at its Channelview and Bayport complexes outside of Houston.

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Novartis has joined forces with researchers from the University of California, Berkeley, to develop new technologies for the discovery of next-generation therapeutics, pursuing the vast number of disease targets in cancer and other illnesses that have eluded traditional small-molecule compounds and are considered “undruggable.”

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